Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001515)
Formula
SVG example
Deiodination
Reactant 3,3',5-triiodothyronine Product Diiodothyronine
Reactant Info Product Info
Metabolic Type Oxidation - Deiodination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001517 Levothyroxine sodium 3,3',5-triiodothyronine Oxidation - Deiodination Levothyroxine sodium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001574 Liothyronine Diiodothyronine Oxidation - Dehalogenation Liothyronine [2]
MR005867 Liothyronine Diiodothyronine Unclear L-thyroxine [3]
MR001516 Reverse triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001573 Diiodothyronine Monoiodothyronine Oxidation - Dehalogenation Liothyronine [2], [5], [6]
References
1 Local activation and inactivation of thyroid hormones: the deiodinase family Mol Cell Endocrinol. 1999 May 25;151(1-2):103-19. doi: 10.1016/s0303-7207(99)00040-4.
2 DrugBank(Pharmacology-Metabolism)Liothyronine
3 Lipoatrophic diabetes: endocrine dysfunction and the response to control hypertriglyceridemia
4 LABEL:EVOTHYROXINE SODIUM injection
5 Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy. Reprod Sci. 2023 Jun;30(6):1758-1769. doi: 10.1007/s43032-022-01162-z.
6 Binding Characteristics of Thyroid Hormone Distributor Proteins to Thyroid Hormone Metabolites. Thyroid. 2022 Aug;32(8):990-999. doi: 10.1089/thy.2021.0588.

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