Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001573)
Formula
SVG example
Dehalogenation
Reactant Diiodothyronine Product Monoiodothyronine
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Metabolic Type Oxidation - Dehalogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001574 Liothyronine Diiodothyronine Oxidation - Dehalogenation Liothyronine [1]
MR001515 3,3',5-triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [2], [3], [4]
MR005867 Liothyronine Diiodothyronine Unclear L-thyroxine [5]
MR001516 Reverse triiodothyronine Diiodothyronine Oxidation - Deiodination Levothyroxine sodium [2]
References
1 DrugBank(Pharmacology-Metabolism)Liothyronine
2 LABEL:EVOTHYROXINE SODIUM injection
3 Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions. Front Pharmacol. 2023 Feb 8;14:1076254. doi: 10.3389/fphar.2023.1076254.
4 Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy. Reprod Sci. 2023 Jun;30(6):1758-1769. doi: 10.1007/s43032-022-01162-z.
5 Lipoatrophic diabetes: endocrine dysfunction and the response to control hypertriglyceridemia

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