Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001539)
Formula
SVG example
Deamination
Reactant L-glutamine Product Glucosamine-6-phosphate
Reactant Info Product Info
Metabolic Enzyme Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (GFPT1) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001542 L-glutamine Amino sugars Unclear L-glutamine [1]
MR001538 L-glutamine Dihydropteroate Unclear L-glutamine [2], [3], [4]
MR001537 L-glutamine L-glutamate Unclear L-glutamine [5], [6], [7]
MR001540 L-glutamine Purines Unclear L-glutamine [1]
MR001541 L-glutamine Pyrimidines Unclear L-glutamine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006377 GlcNAc-6-P GlcN-6-P Unclear Sialic acid [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006378 GlcN-6-P Fructose-6-P Unclear Sialic acid [8]
References
1 The Emerging Role of l-Glutamine in Cardiovascular Health and Disease Nutrients. 2019 Sep 4;11(9):2092. doi: 10.3390/nu11092092.
2 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
3 Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and gamma-aminobutyric acid production. Microb Cell Fact. 2018 Nov 19;17(1):180.
4 GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204.
5 Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation Nutrients. 2018 Oct 23;10(11):1564. doi: 10.3390/nu10111564.
6 The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications Amino Acids. 2016 Sep;48(9):2067-80. doi: 10.1007/s00726-016-2254-8.
7 Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics - synthesis and properties. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1928-1956. doi: 10.1080/14756366.2022.2096018.
8 Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum. Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):725-732.

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