Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001814)
Formula
SVG example
Hydroxylation
Reactant Olaparib Product Olaparib metabolite M10
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001815 Olaparib Olaparib metabolite M1 Hydrolysis - Amide Hydrolysis Olaparib [1]
MR001813 Olaparib Olaparib metabolite M2,M5,M6,M7 Oxidation - Hydroxylation Olaparib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001812 Olaparib metabolite M10 Olaparib metabolite M12 Oxidation - Alcohol Oxidation Olaparib [1]
MR001811 Olaparib metabolite M10 Olaparib metabolite M4 Oxidation - Dehydrogenation Olaparib [1]
References
1 In vitro metabolism of olaparib in liver microsomes by liquid chromatography/electrospray ionization high-resolution mass spectrometry Rapid Commun Mass Spectrom. 2020 Feb 15;34(3):e8575. doi: 10.1002/rcm.8575.

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