Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001949)
Formula	Hydroxylation
	Reactant	Pazopanib		Product	Pazopanib metabolite M1
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Oxidation - Hydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001948	Pazopanib	Pazopanib hydrochloride	Oxidation - Hydroxylation; N-Demethylation	Pazopanib	[1], [2], [3]
MR001950	Pazopanib	Pazopanib metabolite M2	Oxidation - Hydroxylation	Pazopanib	[3]
MR001951	Pazopanib	Pazopanib metabolite M3	Oxidation - N-Demethylation	Pazopanib	[3]

References
1	Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54.
2	Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35.
3	Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642.

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