Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001951)
Formula
SVG example
N-Demethylation
Reactant Pazopanib Product Pazopanib metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001948 Pazopanib Pazopanib hydrochloride Oxidation - Hydroxylation; N-Demethylation Pazopanib [1], [2], [3]
MR001949 Pazopanib Pazopanib metabolite M1 Oxidation - Hydroxylation Pazopanib [3]
MR001950 Pazopanib Pazopanib metabolite M2 Oxidation - Hydroxylation Pazopanib [3]
References
1 Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54.
2 Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35.
3 Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer Xenobiotica. 2013 May;43(5):443-53. doi: 10.3109/00498254.2012.734642.

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