Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002022)
Formula	Conjugation
	Reactant	4-hydroxyphenobarbital	Product	Phenobarbital O-sulfate
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Conjugation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001974	Pentobarbital	4-hydroxyphenobarbital	Oxidation - Hydroxylation	Pentobarbital	[1]
MR002023	Phenobarbital	4-hydroxyphenobarbital	Oxidation - 4-Hydroxylation	Phenobarbital	[2]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002021	4-hydroxyphenobarbital	Phenobarbital N-glucuronide	Conjugation - Conjugation	Phenobarbital	[3]

References
1	CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):821-5.
2	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3	DrugBank(Pharmacology-Metabolism)Phenobarbital

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.