Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001974)
Formula
CYP2C9 ...
SVG example
Hydroxylation
Reactant Pentobarbital Product 4-hydroxyphenobarbital
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001975 Pentobarbital 3'-hydroxypentobarbital Oxidation - Penultimate Oxidation Pentobarbital [1]
MR001977 Pentobarbital Pentobarbital carboxylic acid Oxidation - Oxidation Pentobarbital [2]
MR001976 Pentobarbital Phenobarbitone glucoside Conjugation - Glucuronidation Pentobarbital [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002023 Phenobarbital 4-hydroxyphenobarbital Oxidation - 4-Hydroxylation Phenobarbital [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002021 4-hydroxyphenobarbital Phenobarbital N-glucuronide Conjugation - Conjugation Phenobarbital [4]
MR002022 4-hydroxyphenobarbital Phenobarbital O-sulfate Conjugation - Conjugation Phenobarbital [4]
References
1 American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 2666
2 CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):821-5.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 DrugBank(Pharmacology-Metabolism)Phenobarbital

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