Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002189)
Formula
SVG example
Glucuronidation
Reactant 4'-hydroxypropanolol Product 4-hydroxyalprenolol glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002195 Propranolol hydrochloride 4'-hydroxypropanolol Oxidation - 4-Hydroxylation Propranolol hydrochloride [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002190 4'-hydroxypropanolol Naphthalene-1,4-diol Unclear Propranolol hydrochloride [3]
References
1 Isolation, purification, and structure identification of glucuronic acid conjugates of propranolol and alprenolol and their ring-hydroxylated metabolites Drug Metab Dispos. 1984 Nov-Dec;12(6):749-54.
2 Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography J Chromatogr. 1985 Oct 11;343(2):349-58. doi: 10.1016/s0378-4347(00)84603-4.
3 Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites J Pharmacol Exp Ther. 1972 Jul;182(1):83-92.

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