Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002200)
Formula
SVG example
Reactant 5-hydroxypyrazinamide Product 5-hydroxypyrazinoic acid
Reactant Info Product Info
Metabolic Enzyme Nicotinamidase (pncA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002202 Pyrazinamide 5-hydroxypyrazinamide Oxidation - Oxidation Pyrazinamide [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002199 Pyrazinoic acid 5-hydroxypyrazinoic acid Unclear Pyrazinamide [1], [2], [3]
References
1 Factors Affecting the Pharmacokinetics of Pyrazinamide and Its Metabolites in Patients Coinfected with HIV and Implications for Individualized Dosing Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0004621. doi: 10.1128/AAC.00046-21.
2 Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug Drug Metab Dispos. 2021 Aug;49(8):679-682. doi: 10.1124/dmd.121.000389.
3 Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography J Chromatogr B Biomed Sci Appl. 1997 Aug 1;695(2):365-72. doi: 10.1016/s0378-4347(97)00175-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.