Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002199)
Formula
XDH
SVG example
Reactant Pyrazinoic acid Product 5-hydroxypyrazinoic acid
Reactant Info Product Info
Metabolic Enzyme Xanthine dehydrogenase/oxidase (XDH) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002201 Pyrazinamide Pyrazinoic acid Oxidation - Oxidation Pyrazinamide [1], [2], [3]
MR009315 Pyrazinoylguanidine PZA Unclear - Unclear Pyrazinoylguanidine [4]
MR002363 Telaprevir Pyrazinoic acid Unclear Telaprevir [5]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009317 PZA 2-Pyrazinuric acid Oxidation - C11-hydroxylation Pyrazinoylguanidine [6]
MR009316 PZA OHPZA Unclear - Unclear Pyrazinoylguanidine [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002200 5-hydroxypyrazinamide 5-hydroxypyrazinoic acid Unclear Pyrazinamide [1], [2], [3]
References
1 Factors Affecting the Pharmacokinetics of Pyrazinamide and Its Metabolites in Patients Coinfected with HIV and Implications for Individualized Dosing Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0004621. doi: 10.1128/AAC.00046-21.
2 Metabolism and Hepatotoxicity of Pyrazinamide, an Antituberculosis Drug Drug Metab Dispos. 2021 Aug;49(8):679-682. doi: 10.1124/dmd.121.000389.
3 Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography J Chromatogr B Biomed Sci Appl. 1997 Aug 1;695(2):365-72. doi: 10.1016/s0378-4347(97)00175-8.
4 Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs
5 NCIVEK- telaprevir tablet, film coated Vertex Pharmaceuticals Incorporated
6 A bradykinin antagonist inhibits carrageenan edema in rats

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