Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002257)
Formula
SVG example
Glucuronidation
Reactant Silodosin Product Silodosin glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002256 Silodosin KMD-3241 Oxidation - Dehydrogenation Silodosin [1]
MR002259 Silodosin KMD-3289 Oxidation - Dealkylation Silodosin [1]
MR002258 Silodosin KMD-3293 Oxidation - Dehydrogenation Silodosin [1]
MR002262 Silodosin Silodosin gluosylated metabolite Conjugation - Glucuronidation Silodosin [1]
MR002263 Silodosin Silodosin hydroxylated metabolite Oxidation - Hydroxylation Silodosin [1]
MR002260 Silodosin Silodosin N-dealkylated metabolite Oxidation - N-Dealkylation Silodosin [1]
MR002261 Silodosin Silodosin sulfated metabolite Conjugation - Sulfation Silodosin [1]
References
1 In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites J Mass Spectrom. 2016 Oct;51(10):867-882. doi: 10.1002/jms.3795.

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