Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002260)
Formula
SVG example
N-Dealkylation
Reactant Silodosin Product Silodosin N-dealkylated metabolite
Reactant Info Product Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002256 Silodosin KMD-3241 Oxidation - Dehydrogenation Silodosin [1]
MR002259 Silodosin KMD-3289 Oxidation - Dealkylation Silodosin [1]
MR002258 Silodosin KMD-3293 Oxidation - Dehydrogenation Silodosin [1]
MR002257 Silodosin Silodosin glucuronide Conjugation - Glucuronidation Silodosin [1]
MR002262 Silodosin Silodosin gluosylated metabolite Conjugation - Glucuronidation Silodosin [1]
MR002263 Silodosin Silodosin hydroxylated metabolite Oxidation - Hydroxylation Silodosin [1]
MR002261 Silodosin Silodosin sulfated metabolite Conjugation - Sulfation Silodosin [1]
References
1 In vivo metabolic investigation of silodosin using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites J Mass Spectrom. 2016 Oct;51(10):867-882. doi: 10.1002/jms.3795.

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