Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002268)
Formula Reactant Siponimod metabolite M6 Product Siponimod metabolite M4C
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009616 BAF-312 Siponimod M6 Oxidation - Hydroxylation BAF-312 [1]
MR002271 Siponimod Siponimod metabolite M6 Unclear Siponimod [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009617 Siponimod M6 Siponimod M4c Oxidation - Sulfonation BAF-312 [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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