Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002281)
Formula
SVG example
5-Hydroxylation
Reactant Sulfamethoxazole Product 5-hydroxysulfamethoxazole
Reactant Info Product Info
Metabolic Type Oxidation - 5-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002282 Sulfamethoxazole N-acetylsulfamethoxazole Conjugation - Acetylation Sulfamethoxazole [1]
MR002283 Sulfamethoxazole Sulfamethoxazole N-glucuronide Conjugation - N-Glucuronidation Sulfamethoxazole [1]
MR002280 Sulfamethoxazole Sulfamethoxazole N4-hydroxylamine Oxidation - N-Hydroxylation Sulfamethoxazole [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002278 5-hydroxysulfamethoxazole N4-Acetyl-5-OH-sulfamethoxazole Conjugation - Acetylation Sulfamethoxazole [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. J Immunol. 2007 May 1;178(9):5533-42.
3 The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus. J Clin Pharmacol. 1998 May;38(5):463-6.

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