Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002383)
Formula
SVG example
Reactant Temsirolimus Product N-oxide temsirolimus
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002388 Temsirolimus . Unclear Temsirolimus [1]
MR002382 Temsirolimus 11-hydroxyl temsirolimus Unclear Temsirolimus [2]
MR002386 Temsirolimus 25-hydroxy temsirolimus Oxidation - Hydroxylation Temsirolimus [3]
MR002385 Temsirolimus 27-O-desmethyl temsirolimus Oxidation - O-Demethylation Temsirolimus [3]
MR002384 Temsirolimus 32-O-desmethyl temsirolimus Unclear Temsirolimus [2]
MR002381 Temsirolimus 35-hydroxyl temsirolimus Unclear Temsirolimus [2]
MR002380 Temsirolimus 36-hydroxyl temsirolimus Unclear Temsirolimus [2]
MR002387 Temsirolimus Hydroxy-piperidine temsirolimus Oxidation - Hydroxylation Temsirolimus [3]
MR002389 Temsirolimus Sirolimus Hydrolysis - Hydrolysis Temsirolimus [4]
References
1 Drug Interactions Flockhart Table:Docetaxel
2 In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites Drug Metab Dispos. 2007 Sep;35(9):1554-63. doi: 10.1124/dmd.107.014746.
3 Temsirolimus metabolic pathways revisited Xenobiotica. 2020 Jun;50(6):640-653. doi: 10.1080/00498254.2019.1678793.
4 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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