Details of the Metabolic Reaction (MR)
| General Information of This Metabolic Reaction (MR) (ID: MR002399) | ||||||
|---|---|---|---|---|---|---|
| Formula | Reactant | Hydroxyterbinafine | Product | N-Desmethylhydroxyterbinafine | ||
| Reactant Info | Product Info | |||||
| Metabolic Enzyme | Cytochrome P450 3A4 (CYP3A4) | DME Info | ||||
| Cytochrome P450 1A2 (CYP1A2) | DME Info | |||||
| Cytochrome P450 2B6 (CYP2B6) | DME Info | |||||
| Cytochrome P450 2C8 (CYP2C8) | DME Info | |||||
| Cytochrome P450 2C9 (CYP2C9) | DME Info | |||||
| Mephenytoin 4-hydroxylase (CYP2C19) | DME Info | |||||
| Metabolic Type | Oxidation - N-Demethylation | |||||
| Other MR(s) Related to The Reactant of This MR | |||||||||||||||||||||||||||||
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| Other MR(s) That Metabolize The Reactant of This MR | |||||||||||||||||||||||||||||
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| Other MR(s) Related to The Product of This MR | |||||||||||||||||||||||||||||
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| References | ||||||
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| 1 | Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38. | |||||
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