Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002442)
Formula
SVG example
Reactant Trazodone hydrochloride Product Triazolopyridinone epoxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002443 Trazodone hydrochloride 4'-hydroxytrazodone Oxidation - Hydroxylation Trazodone hydrochloride [1]
MR002444 Trazodone hydrochloride M-chlorophenylpiperazine Oxidation - N-Dealkylation Trazodone hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002437 Triazolopyridinone epoxide Trazodone hydrochloride M2 Unclear Trazodone hydrochloride [1]
MR002438 Triazolopyridinone epoxide Trazodone hydrochloride M3 Conjugation - Glutathione Conjugation Trazodone hydrochloride [1]
MR002439 Triazolopyridinone epoxide Trazodone hydrochloride MQ Unclear Trazodone hydrochloride [1]
References
1 Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20.
2 Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats Int J Neuropsychopharmacol. 1999 Mar;2(1):17-23. doi: 10.1017/S1461145799001303.

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