Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002540)
Formula
SVG example
Reactant Chenodeoxycholic acid Product Lithocholic acid
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002541 Chenodeoxycholic acid 7alpha-hydroxy-3-oxo-5beta-cholan-24-oic Acid Oxidation - Oxidation Chenodeoxycholic acid [1]
MR002546 Chenodeoxycholic acid Chenodeoxycholic acid glucuronide Unclear Chenodeoxycholic acid [2]
MR002543 Chenodeoxycholic acid Chenodeoxycholic acid sulfolithocholyl metabolite Unclear Chenodeoxycholic acid [1]
MR002545 Chenodeoxycholic acid Cholic acid Unclear Chenodeoxycholic acid [3]
MR002542 Chenodeoxycholic acid Gamma-muricholic acid Unclear Chenodeoxycholic acid [1]
MR002544 Chenodeoxycholic acid Taurine Unclear Chenodeoxycholic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003853 Bile acid LCA Unclear Bile acid [4]
MR002483 Ursodeoxycholic acid Lithocholic acid Unclear Ursodeoxycholic acid [5]
MR003850 UDCA LCA Unclear Bile acid [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003851 LCA Hyodexycholic acid Unclear Bile acid [4]
MR003852 LCA Murideoxycholic acid Unclear Bile acid [4]
References
1 Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. Drug Metab Dispos. 2008 Oct;36(10):1983-91.
2 Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov;44(5):1158-70.
3 Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biol Chem. 2019 Apr 24;400(5):625-628.
4 Bile Acid Metabolism in Liver Pathobiology
5 Pharmacology of ursodeoxycholic acid, an enterohepatic drug Scand J Gastroenterol Suppl. 1994;204:1-15. doi: 10.3109/00365529409103618.

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