Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002710)
Formula
SVG example
Reactant N-desmethylzopiclone Product 2-amino-5-chloropyridine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002713 Eszopiclone N-desmethylzopiclone Oxidation - N-Demethylation Eszopiclone [1]
MR002720 Ethinyl estradiol N-desmethylzopiclone Conjugation - O-Glucuronidation Ethinyl estradiol [2]
MR009651 Zopiclone N-desmethylzopiclone Oxidation - N-demethylation Zopiclone [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002712 Eszopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [1]
MR002709 Zopiclone N-oxide 2-amino-5-chloropyridine Unclear Eszopiclone [1]
References
1 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.
2 Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol Mol Pharmacol. 1993 Apr;43(4):649-54.
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 Distribution of zopiclone and main metabolites in hair following a single dose

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