Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002714)
Formula
SVG example
Oxidative Decarboxylation
Reactant Eszopiclone Product Carbon dioxide
Reactant Info Product Info
Metabolic Type Oxidation - Oxidative Decarboxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002712 Eszopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [1]
MR002713 Eszopiclone N-desmethylzopiclone Oxidation - N-Demethylation Eszopiclone [1]
MR002711 Eszopiclone Zopiclone N-oxide Oxidation - N-Oxidation Eszopiclone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013804 Acetohydroxamic Acid CO2 Unclear - Unclear Acetohydroxamic Acid [2]
MR009216 Acetylcarnitine CO2 Oxidation - Oxidation Acetylcarnitine [3]
MR004185 D-lactic acid Carbon dioxide Oxidation - Oxidationn D-lactic acid [4]
MR003888 DB-053072 Carbon dioxide Unclear DB-053072 [5]
MR006290 Diethylenetriamine Carbon dioxide Unclear Diethylenetriamine [6]
MR005861 L-tyrosine Carbon dioxide Unclear L-tyrosine [7]
MR001579 Liraglutide Carbon dioxide Unclear Liraglutide [8]
MR004251 Methylamine Carbon dioxide Unclear Methylamine [9]
MR006821 Sodium acetate Carbon dioxide Hydrolysis - Hydrolysis Sodium acetate [10]
MR005892 Stigmasterol Carbon dioxide Unclear Stigmasterol [11]
MR006225 Urethane Carbon dioxide Unclear Urethane [12]
MR009650 Zopiclone Carbon dioxide Oxidation - Oxidative decarboxylation Zopiclone [13]
MR007847 Formic acid CO2 Unclear - Unclear Fospropofol disodium [14]
MR006838 Glucose Carbon dioxide Unclear Sorbitol [15]
MR006825 Succinic Acid Carbon dioxide Oxidation - Oxidationn Sodium oxybate [16]
MR004036 Urea Carbon dioxide Unclear Xanthine [17]
MR007512 Allantoic acid Carbon dioxide Unclear Inosine [18]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003889 Carbon dioxide Bicarbonate Unclear DB-053072 [5]
MR006822 Carbon dioxide Bicarbonate Reduction - Hydrogenation Sodium acetate [10]
References
1 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.
2 Disposition of 14C-acetohydroxamic acid and 14C-acetamide in the rat
3 Partial purification and characterization of an acetylcarnitine hydrolase from bovine epididymal spermatozoa
4 [D(-)Lactic acid--a metabolism problem]
5 Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-(13)C]Pyruvate
6 Pharmacokinetics and material balance studies of diethylenetriamine trihydrochloride in the Fischer 344 rat following oral, endotracheal or intravenous dosing
7 Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
8 Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010 Nov;38(11):1944-53.
9 Microbial metabolism of methanol and methylamine in the Gulf of Mexico: insight into marine carbon and nitrogen cycling
10 Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans. J Nutr. 2007 Jul;137(7):1750-6.
11 Degradation of phytosterols in tobacco waste extract by a novel Paenibacillus sp. Biotechnol Appl Biochem. 2017 Nov;64(6):843-850.
12 Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice
13 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
14 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
15 An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 1498
16 Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. J Inherit Metab Dis. 2005;28(6):921-30.
17 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism
18 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos

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