Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002782)
Formula
CYP1A2 ...
SVG example
N-Demethylation
Reactant Promazine Product N-Desmethylpromazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002784 Promazine 3-hydroxypromazine Oxidation - Hydroxylation Promazine [1]
MR002783 Promazine Phenothiazine Unclear Promazine [2]
MR002781 Promazine Promazine 5-sulfoxide Oxidation - 5-Sulphoxidation Promazine [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development Curr Med Chem. 2009;16(27):3480-675. doi: 10.2174/092986709789057635.
2 Hazardous Substances Data Bank:Promazine

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