Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002815)
Formula
SVG example
24-Hydroxylation
Reactant Calcitriol Product Calcitroic acid
Reactant Info Product Info
Metabolic Enzyme Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info
Metabolic Type Oxidation - 24-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002816 Calcitriol 1a,25R(OH)2-26,23S-lactone D3 Oxidation - Hydroxylation Calcitriol [1], [2]
MR002817 Calcitriol Calcitriol 25-O-glucuronide Conjugation - Glucuronidation Calcitriol [3]
MR002814 Calcitriol 1a,25R(OH)2-26,23S-lactone D3 Oxidation - Hydroxylation Calcifediol [2]
MR010849 Calcitriol 1,24,25(OH)2D3 Unclear - Unclear Cholecalciferol [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000113 1,25-dihydroxyvitamin D3 Calcitroic Acid Unclear Alfacalcidol [5]
References
1 Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006 Jan;69(1):56-65.
2 Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99.
3 Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochem Pharmacol. 2008 Mar 1;75(5):1240-50.
4 Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice
5 Metabolism of 1,25-dihydroxyvitamin D3 Physiol Rev. 1984 Apr;64(2):478-504. doi: 10.1152/physrev.1984.64.2.478.

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