Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002816)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Calcitriol Product 1a,25R(OH)2-26,23S-lactone D3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002817 Calcitriol Calcitriol 25-O-glucuronide Conjugation - Glucuronidation Calcitriol [1]
MR002815 Calcitriol Calcitroic acid Oxidation - 24-Hydroxylation Calcitriol [2]
MR002813 Calcitriol Calcitroic acid Oxidation - 24-Hydroxylation Calcifediol [3]
MR010849 Calcitriol 1,24,25(OH)2D3 Unclear - Unclear Cholecalciferol [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000114 1,25-dihydroxyvitamin D3 1,25-dihydroxyvitamin D3-26,23-lactone Unclear Alfacalcidol [5]
References
1 Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochem Pharmacol. 2008 Mar 1;75(5):1240-50.
2 Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006 Jan;69(1):56-65.
3 Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99.
4 Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice
5 A new look at the most successful prodrugs for active vitamin D (D hormone): alfacalcidol and doxercalciferol Molecules. 2009 Sep 29;14(10):3869-80. doi: 10.3390/molecules14103869.

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