Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002847)
Formula
SVG example
Glucuronidation
Reactant Epinephrine hydrochloride Product Epinephrine glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002849 Epinephrine hydrochloride Dihydroxymandelic acid Unclear Epinephrine hydrochloride [1]
MR002846 Epinephrine hydrochloride Epinephrine sulfate metabolite Conjugation - Sulfation Epinephrine hydrochloride [2]
MR002848 Epinephrine hydrochloride Metanephrine Conjugation - O-Methylation Epinephrine hydrochloride [1]
References
1 Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther. 1994 Mar;268(3):1242-51.
2 Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23.

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