Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002955)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Nicotine Product Nicotine glucuronide metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002960 Nicotine (S)-Nicotine delta-1',5'-iminium ion Oxidation - Heteroring Dehydrogenation Nicotine [1]
MR002961 Nicotine 2'-hydroxynicotine Oxidation - Hydroxylation Nicotine [2]
MR002959 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Unclear Nicotine [3]
MR002958 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Unclear Nicotine [3]
MR002963 Nicotine Cotinine Unclear Nicotine [3]
MR002954 Nicotine N-Methylnicotinium Unclear Nicotine [4]
MR002953 Nicotine Nicotine imine Unclear Nicotine [4]
MR002957 Nicotine Nicotine-1'-N-oxide Oxidation - 1'-N-Oxidation Nicotine [4]
MR002956 Nicotine Norcotinine Unclear Nicotine [3]
MR002952 Nicotine Nornicotine Unclear Nicotine [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
3 DrugBank(Pharmacology-Metabolism)Nicotine
4 U. S. FDA Label -Nicotine

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