Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002960)
Formula
CYP2B6 ...
SVG example
Heteroring Dehydrogenation
Reactant Nicotine Product (S)-Nicotine delta-1',5'-iminium ion
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Heteroring Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002961 Nicotine 2'-hydroxynicotine Oxidation - Hydroxylation Nicotine [1]
MR002959 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol Unclear Nicotine [2]
MR002958 Nicotine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Unclear Nicotine [2]
MR002963 Nicotine Cotinine Unclear Nicotine [2]
MR002954 Nicotine N-Methylnicotinium Unclear Nicotine [3]
MR002955 Nicotine Nicotine glucuronide metabolite Conjugation - Glucuronidation Nicotine [4]
MR002953 Nicotine Nicotine imine Unclear Nicotine [3]
MR002957 Nicotine Nicotine-1'-N-oxide Oxidation - 1'-N-Oxidation Nicotine [3]
MR002956 Nicotine Norcotinine Unclear Nicotine [2]
MR002952 Nicotine Nornicotine Unclear Nicotine [2]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 DrugBank(Pharmacology-Metabolism)Nicotine
3 U. S. FDA Label -Nicotine
4 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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