Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003047)
Formula
SVG example
Monohydroxylation
Reactant Atazanavir Product Atazanavir metabolite M2
Reactant Info Product Info
Metabolic Type Oxidation - Monohydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003055 Atazanavir Atazanavir metabolite M1 Oxidation - Dealkylation Atazanavir [1]
MR003060 Atazanavir Atazanavir metabolite M13 Hydrolysis - Hydrolysis Atazanavir [1]
MR003061 Atazanavir Atazanavir metabolite M14 Hydrolysis - Hydrolysis Atazanavir [1]
MR003062 Atazanavir Atazanavir metabolite M15 Unclear Atazanavir [1]
MR003063 Atazanavir Atazanavir metabolite M15' Oxidation - Dealkylation Atazanavir [1]
MR003057 Atazanavir Atazanavir metabolite M3 Oxidation - Monohydroxylation Atazanavir [1]
MR003058 Atazanavir Atazanavir metabolite M4 Oxidation - Monohydroxylation Atazanavir [1]
MR003059 Atazanavir Atazanavir metabolite M5 Oxidation - Monohydroxylation Atazanavir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003050 Atazanavir metabolite M2 Atazanavir metabolite M10 Oxidation - Dihydroxylation Atazanavir [1]
MR003054 Atazanavir metabolite M2 Atazanavir metabolite M12 Unclear Atazanavir [1]
MR003052 Atazanavir metabolite M2 Atazanavir metabolite M6 Other reaction - Monodehydrogenation Atazanavir [1]
MR003053 Atazanavir metabolite M2 Atazanavir metabolite M7 Other reaction - Monodehydrogenation Atazanavir [1]
MR003048 Atazanavir metabolite M2 Atazanavir metabolite M8 Unclear Atazanavir [1]
References
1 CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism Drug Metab Dispos. 2011 Mar;39(3):394-401. doi: 10.1124/dmd.110.036327.

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