Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003118)
Formula
CTSA ...
SVG example
Hydrolyzation
Reactant Tenofovir disoproxil fumarate Product Tenofovir
Reactant Info Product Info
Metabolic Enzyme Cathepsin A (CTSA) DME Info
Carboxylesterase 1 (CES1) DME Info
Metabolic Type Hydrolysis - Hydrolyzation
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003116 Tenofovir alafenamide Tenofovir Hydrolysis - Hydrolyzation Tenofovir alafenamide [1]
MR010851 Ala-TFV Tenofovir(TFV) Unclear - Unclear GS-7340 [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010852 Tenofovir(TFV) Tenofovir-DP Unclear - Unclear GS-7340 [2]
References
1 Bictegravir/Emtricitabine/Tenofovir Alafenamide: a review in HIV-1 infection. Drugs. 2018 Nov;78(17):1817-1828.
2 Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
3 Tenofovir alafenamide in the treatment of chronic hepatitis B virus infection: rationale and clinical trial evidence

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