Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010851)
Formula
SVG example
Unclear
Reactant Ala-TFV Product Tenofovir(TFV)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010850 GS-7340 Ala-TFV Unclear - Unclear GS-7340 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003116 Tenofovir alafenamide Tenofovir Hydrolysis - Hydrolyzation Tenofovir alafenamide [2]
MR003118 Tenofovir disoproxil fumarate Tenofovir Hydrolysis - Hydrolyzation Tenofovir disoproxil fumarate [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010852 Tenofovir(TFV) Tenofovir-DP Unclear - Unclear GS-7340 [1]
References
1 Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy
2 Bictegravir/Emtricitabine/Tenofovir Alafenamide: a review in HIV-1 infection. Drugs. 2018 Nov;78(17):1817-1828.

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