Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003149)
Formula
SVG example
Reactant Dehydroepiandrosterone Product 4-androstene-3,17-dione(AD)
Reactant Info Product Info
Metabolic Enzyme Dihydrotestosterone oxidoreductase (HSD3B1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003150 Dehydroepiandrosterone Dehydroepiandrosterone sulfate metabolite Unclear Dehydroepiandrosterone [1]
MR005803 Dehydroepiandrosterone Testosterone Unclear Prasterone sulfate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004537 AC-12166 Androst-4-ene-3,17-dione (4ADN) Unclear AC-12166 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003145 4-androstene-3,17-dione(AD) Estradiol-17 beta Unclear Dehydroepiandrosterone [1]
MR003147 4-androstene-3,17-dione(AD) Estrone Unclear Dehydroepiandrosterone [1]
MR003146 4-androstene-3,17-dione(AD) Testosterone Unclear Dehydroepiandrosterone [1]
References
1 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.
2 Toxin and Toxin Target Database (T3DB):Prasterone sulfate
3 Conversion of 4-androstenediol and 5-androstenediol to testosterone, and conversion of dehydroepiandrosterone to 4-androstenediol by rat testis in vitro

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