Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003151)
Formula
SVG example
Reactant Estrone Product Estrone sulfate
Reactant Info Product Info
Metabolic Enzyme Aromatase (CYP19A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002705 Estrone 15alpha-OH-estrone Unclear Estrone [1]
MR002706 Estrone 16alpha-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002707 Estrone 16beta-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002696 Estrone 2-hydroxyestrone Oxidation - 2-Hydroxylation Estrone [2]
MR002699 Estrone 2-hydroxyestrone sulfate Unclear Estrone [3]
MR002697 Estrone 4-hydroxyestrone Oxidation - 4-Hydroxylation Estrone [2]
MR002700 Estrone 4-hydroxyestrone sulfate Unclear Estrone [3]
MR002701 Estrone 4-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002702 Estrone 6alpha-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002703 Estrone 6beta-estrone Unclear Estrone [1]
MR002704 Estrone 7alpha-OH-estrone Unclear Estrone [1]
MR002698 Estrone Estrone glucuronide Conjugation - Glucuronidation Estrone [3]
MR004102 Estrone Estriol Oxidation - Hydrolyzationn Conjugated estrogens [4]
MR013310 Estrone 16-alpha hydroxyestrone Unclear E-3A [5]
MR002645 Estrone 16alpha hydroxyestrone Unclear Estradiol acetate [5]
MR002668 Estrone 16alpha hydroxyestrone Unclear Estradiol cypionate [5]
MR002691 Estrone 16alpha hydroxyestrone Unclear Estradiol valerate [5]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
3 DrugBank(Pharmacology-Metabolism)Estrone
4 DrugBank(Pharmacology-Metabolism):Conjugated estrogens
5 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.

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