Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004102)
Formula
SVG example
Hydrolyzationn
Reactant Estrone Product Estriol
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002705 Estrone 15alpha-OH-estrone Unclear Estrone [1]
MR002706 Estrone 16alpha-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002707 Estrone 16beta-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002696 Estrone 2-hydroxyestrone Oxidation - 2-Hydroxylation Estrone [2]
MR002699 Estrone 2-hydroxyestrone sulfate Unclear Estrone [3]
MR002697 Estrone 4-hydroxyestrone Oxidation - 4-Hydroxylation Estrone [2]
MR002700 Estrone 4-hydroxyestrone sulfate Unclear Estrone [3]
MR002701 Estrone 4-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002702 Estrone 6alpha-OH-estrone Oxidation - Hydroxylation Estrone [1]
MR002703 Estrone 6beta-estrone Unclear Estrone [1]
MR002704 Estrone 7alpha-OH-estrone Unclear Estrone [1]
MR002698 Estrone Estrone glucuronide Conjugation - Glucuronidation Estrone [3]
MR002708 Estrone Estrone sulfate Unclear Estrone [3]
MR013321 Estrone Estrone sulfate Unclear E-3A [4]
MR013310 Estrone 16-alpha hydroxyestrone Unclear E-3A [5]
MR002646 Estrone Estrone sulfate Unclear Estradiol acetate [4]
MR002669 Estrone Estrone sulfate Unclear Estradiol cypionate [4]
MR002692 Estrone Estrone sulfate Unclear Estradiol valerate [4]
MR003151 Estrone Estrone sulfate Unclear Dehydroepiandrosterone [6]
MR002645 Estrone 16alpha hydroxyestrone Unclear Estradiol acetate [5]
MR002668 Estrone 16alpha hydroxyestrone Unclear Estradiol cypionate [5]
MR002691 Estrone 16alpha hydroxyestrone Unclear Estradiol valerate [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004242 Estrone sulfate Estriol Unclear Estrone sulfate [7]
MR000966 Estropipate Estriol Unclear Estropipate [8]
MR013312 16-alpha hydroxyestrone Estriol Unclear E-3A [5]
MR003144 17-beta-estradiol Estriol Unclear Dehydroepiandrosterone [9]
MR002639 16alpha hydroxyestrone Estriol Unclear Estradiol acetate [5]
MR002662 16alpha hydroxyestrone Estriol Unclear Estradiol cypionate [5]
MR002685 16alpha hydroxyestrone Estriol Unclear Estradiol valerate [5]
⏷ Show the Full List of MR
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
3 DrugBank(Pharmacology-Metabolism)Estrone
4 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
5 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
6 Dehydroepiandrosterone Research: Past, Current, and Future Vitam Horm. 2018;108:1-28. doi: 10.1016/bs.vh.2018.02.002.
7 DrugBank(Pharmacology-Metabolism):Estrone sulfate
8 DrugBank(Pharmacology-Metabolism)Estropipate
9 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.

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