Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003262)
Formula
UGT1A8 ...
SVG example
Glucuronidation
Reactant Propofol Product Propofol glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002187 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation Propofol [1]
MR007843 Propofol 2-(omega-Propanol)-6-isopropyl-phenol Unclear - Unclear Fospropofol disodium [2]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear Fospropofol [3]
MR003261 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation Fospropofol [1]
MR007835 Propofol 4-Hydroxypropofol Unclear - Unclear Fospropofol disodium [2]
MR007850 Propofol Propofol-O-glucuronide Conjugation - O-glucuronidation Fospropofol disodium [2]
MR007849 Propofol Propofol-O-sulfate Unclear - Unclear Fospropofol disodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002186 Propofol glucuronide 1-Quinol glucuronide Oxidation - 4-Hydroxylation Propofol [1]
MR003255 Propofol glucuronide 4-hydroxymethylpyrazole Oxidation - 4-Hydroxylation Fospropofol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
3 DrugBank(Pharmacology-Metabolism)Fospropofol

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