Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003260)
Formula
SVG example
Reactant Propofol Product 4-hydroxymethylpyrazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002187 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation Propofol [1]
MR002188 Propofol Propofol glucuronide Conjugation - Glucuronidation Propofol [1]
MR007843 Propofol 2-(omega-Propanol)-6-isopropyl-phenol Unclear - Unclear Fospropofol disodium [2]
MR003261 Propofol 4-hydroxypropofol Oxidation - 4-Hydroxylation Fospropofol [1]
MR007835 Propofol 4-Hydroxypropofol Unclear - Unclear Fospropofol disodium [2]
MR003262 Propofol Propofol glucuronide Conjugation - Glucuronidation Fospropofol [1]
MR007850 Propofol Propofol-O-glucuronide Conjugation - O-glucuronidation Fospropofol disodium [2]
MR007849 Propofol Propofol-O-sulfate Unclear - Unclear Fospropofol disodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001086 Fomepizole 4-hydroxymethylpyrazole Unclear Fomepizole [3]
MR005975 GTPL-463 4-hydroxymethylpyrazole Unclear GTPL-463 [4]
MR003255 Propofol glucuronide 4-hydroxymethylpyrazole Oxidation - 4-Hydroxylation Fospropofol [1]
MR003254 4-Quinol sulfate 4-hydroxymethylpyrazole Conjugation - Glucuronidation Fospropofol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
3 DrugBank(Pharmacology-Metabolism)Fomepizole
4 DrugBank(Pharmacology-Metabolism):GTPL-463 Fomepizole

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