Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003345)
Formula
SVG example
Reactant N-desmethyl apalutamide Product Apalutamide metabolite M4
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003361 Apalutamide N-desmethyl apalutamide Oxidation - N-Demethylation Apalutamide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003343 N-desmethyl apalutamide Apalutamide metabolite M12 Unclear Apalutamide [1]
MR003344 N-desmethyl apalutamide Apalutamide metabolite M14 Unclear Apalutamide [1]
MR003346 N-desmethyl apalutamide Apalutamide metabolite M5 Unclear Apalutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003364 Apalutamide Apalutamide metabolite M4 Hydrolysis - Amide Hydrolysis Apalutamide [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003353 Apalutamide metabolite M4 Apalutamide metabolite M18 Unclear Apalutamide [1]
MR003352 Apalutamide metabolite M4 Apalutamide metabolite M17 Unclear Apalutamide [1]
References
1 Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517.

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