Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003343)
Formula Reactant N-desmethyl apalutamide Product Apalutamide metabolite M12
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003361 Apalutamide N-desmethyl apalutamide Oxidation - N-Demethylation Apalutamide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003344 N-desmethyl apalutamide Apalutamide metabolite M14 Unclear Apalutamide [1]
MR003345 N-desmethyl apalutamide Apalutamide metabolite M4 Unclear Apalutamide [1]
MR003346 N-desmethyl apalutamide Apalutamide metabolite M5 Unclear Apalutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003349 Apalutamide metabolite M10 Apalutamide metabolite M12 Unclear Apalutamide [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003347 Apalutamide metabolite M12 Apalutamide metabolite M14 Unclear Apalutamide [1]
References
1 Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517.

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