Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003447)
Formula
CYP3A4 ...
SVG example
Reactant Edoxaban Product Edoxaban metabolite M7
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003451 Edoxaban Edoxaban metabolite M1 Unclear Edoxaban [1]
MR003452 Edoxaban Edoxaban metabolite M2 Unclear Edoxaban [1]
MR003453 Edoxaban Edoxaban metabolite M3 Unclear Edoxaban [1]
MR003454 Edoxaban Edoxaban metabolite M4 Hydrolysis - Hydrolysis Edoxaban [1]
MR003450 Edoxaban Edoxaban metabolite M5 Unclear Edoxaban [1]
MR003449 Edoxaban Edoxaban metabolite M6 Unclear Edoxaban [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003448 Edoxaban metabolite M7 Edoxaban metabolite M8 Unclear Edoxaban [1]
References
1 Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans Drug Metab Dispos. 2012 Dec;40(12):2250-5. doi: 10.1124/dmd.112.046888.

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