Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003523)
Formula Reactant Alpha-hydroxytamoxifen Product Alpha-tamoxifen sulfate
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A2 (SULT1A2) DME Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003522 Tamoxifen citrate Alpha-hydroxytamoxifen Oxidation - Hydroxylation Tamoxifen citrate [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003524 Alpha-hydroxytamoxifen Alpha-hydroxytamoxifen glucuronide Conjugation - Sulfation Tamoxifen citrate [3]
References
1 [Effect of lithium on the hematopoietic stem cells] Acta Haematol Pol. 1989 Jan-Jun;20(1):99-106.
2 The tamoxifen dilemma. Carcinogenesis. 1999 Jul;20(7):1153-60.
3 PharmGKB:Tamoxifen citrate

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