Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003524)
Formula Reactant Alpha-hydroxytamoxifen Product Alpha-hydroxytamoxifen glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Sulfation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003522 Tamoxifen citrate Alpha-hydroxytamoxifen Oxidation - Hydroxylation Tamoxifen citrate [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003523 Alpha-hydroxytamoxifen Alpha-tamoxifen sulfate Conjugation - Sulfation Tamoxifen citrate [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005294 Cis-4-hydroxytamoxifen Cis-4-hydroxytamoxifen-O-glucuronide Conjugation - Glucuronidation Cis-4-hydroxytamoxifen [4]
References
1 [Effect of lithium on the hematopoietic stem cells] Acta Haematol Pol. 1989 Jan-Jun;20(1):99-106.
2 The tamoxifen dilemma. Carcinogenesis. 1999 Jul;20(7):1153-60.
3 PharmGKB:Tamoxifen citrate
4 Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14.

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