Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003715)
Formula
SVG example
Ester hydrolysis
Reactant Sacubitril Product LBQ657
Reactant Info Product Info
Metabolic Type Hydrolysis - Ester hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003714 LCZ-696 Sacubitril Hydrolysis - Ester hydrolysis LCZ-696 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003721 Sacubitril LCZ-696 Metabolite M2 Unclear LCZ-696 [1]
MR003723 Sacubitril LCZ-696 Metabolite M3 Unclear LCZ-696 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010568 LCZ696 Sacubitrilat LBQ657 Unclear - Unclear LCZ696 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003716 LBQ657 LCZ-696 Metabolite M4 Unclear LCZ-696 [1]
MR003717 LBQ657 LCZ-696 Metabolite M5 Unclear LCZ-696 [1]
MR003718 LBQ657 LCZ-696 Metabolite M6 Oxidation - Oxidationn LCZ-696 [1]
MR003719 LBQ657 LCZ-696 Metabolite M7 Oxidation - Oxidationn LCZ-696 [1]
MR003720 LBQ657 LCZ-696 Metabolite M8 Unclear LCZ-696 [1]
References
1 Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects
2 An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension

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