Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003723)
Formula Reactant Sacubitril Product LCZ-696 Metabolite M3
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003714 LCZ-696 Sacubitril Hydrolysis - Ester hydrolysis LCZ-696 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003715 Sacubitril LBQ657 Hydrolysis - Ester hydrolysis LCZ-696 [2], [3], [1]
MR003721 Sacubitril LCZ-696 Metabolite M2 Unclear LCZ-696 [1]
References
1 Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects
2 Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
3 Dicarboxylic acid dipeptide neutral endopeptidase inhibitors

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