Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003752)
Formula Reactant LY-2484595 Product LY-2484595 Metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003757 LY-2484595 LY-2484595 Metabolite M10 Conjugation - Glucuronidation LY-2484595 [1]
MR003747 LY-2484595 LY-2484595 Metabolite M2 Oxidation - Oxidationn LY-2484595 [1]
MR003753 LY-2484595 LY-2484595 Metabolite M4 Oxidation - Oxidationn LY-2484595 [1]
MR003754 LY-2484595 LY-2484595 Metabolite M5 Oxidation - Oxidationn LY-2484595 [1]
MR003755 LY-2484595 LY-2484595 Metabolite M8 Oxidation - Oxidationn LY-2484595 [1]
MR003756 LY-2484595 LY-2484595 Metabolite M9 Oxidation - Oxidationn LY-2484595 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003762 LY-450139 LY-2484595 Metabolite M3 Oxidation - Benzylic hydroxylation LY-450139 [2]
References
1 Evacetrapib: in?vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors
2 Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.

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