Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004094)
Formula
SVG example
N-demethylation
Reactant Codeine Product Norcodeine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004100 Codeine Codeine-6-glucuronide Unclear Codeine [1]
MR004096 Codeine Morphine Conjugation - Glucuronidation Codeine [2], [3], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004095 Norcodeine Normorphine Oxidation - O-demethylation Codeine [1]
References
1 Pharmacogenetics of analgesic drugs
2 Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity
3 Pharmacokinetics and metabolism of codeine in humans

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