Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004096)
Formula	UGT2B7 Glucuronidation
	Reactant	Codeine	Product	Morphine
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	UDP-glucuronosyltransferase 2B7 (UGT2B7)				DME Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR004100	Codeine	Codeine-6-glucuronide	Unclear	Codeine	[1]
MR004094	Codeine	Norcodeine	Oxidation - N-demethylation	Codeine	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR012868	Ethylmorphine	Morphine	Oxidation - N-dealkylation	Ethylmorphine	[2], [3], [4], [5]
MR013331	6-Monoacetylmorphine	Morphine	Oxidation - Deacetylation	Heroin	[6]

References
1	Pharmacogenetics of analgesic drugs
2	Ethylmorphine metabolism in isolated rat hepatocytes
3	Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity
4	Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
5	Metabolism and pharmacokinetics of morphine in neonates: A review
6	Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.