Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004248)
Formula
SVG example
Deamination
Reactant Methylamine Product Formaldehyde
Reactant Info Product Info
Metabolic Enzyme Semicarbazide-sensitive amine oxidase (AOC2) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004251 Methylamine Carbon dioxide Unclear Methylamine [1]
MR004252 Methylamine NH4+ Unclear Methylamine [1]
MR002920 Methylamine Dihydrolipoamide Unclear Glycine [2]
MR004249 Methylamine H2O2 Oxidation - Deamination Methylamine [3]
MR004250 Methylamine Ammonia Oxidation - Deamination Methylamine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004593 Darodipine Formaldehyde Oxidation - N-demethylation; O-demethylation Darodipine [4]
MR006665 Doxepin hydrochloride Formaldehyde Oxidation - N-demethylation Doxepin hydrochloride [5]
MR003257 Fospropofol Formaldehyde Unclear Fospropofol [6]
MR007845 Fospropofol disodium Formaldehyde Unclear - Unclear Fospropofol disodium [7]
MR000289 N-hydroxymethyl-aripiprazole Formaldehyde Hydrolysis - Hydrolysis Aripiprazole lauroxil [8], [9]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007846 Formaldehyde Formic acid Unclear - Unclear Fospropofol disodium [7]
References
1 Microbial metabolism of methanol and methylamine in the Gulf of Mexico: insight into marine carbon and nitrogen cycling
2 DrugBank(Pharmacology-Metabolism)Glycine
3 Deamination of methylamine and angiopathy; toxicity of formaldehyde, oxidative stress and relevance to protein glycoxidation in diabetes
4 Inhibition of hepatic microsomal drug metabolism in rats by five calcium antagonists
5 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
6 DrugBank(Pharmacology-Metabolism)Fospropofol
7 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
8 Aripiprazole Lauroxil: Pharmacokinetic Profile of This Long-Acting Injectable Antipsychotic in Persons With Schizophrenia J Clin Psychopharmacol. 2017 Jun;37(3):289-295. doi: 10.1097/JCP.0000000000000691.
9 Biological conversion of?aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug Results Pharma Sci. 2014 May 2;4:19-25. doi: 10.1016/j.rinphs.2014.04.002.

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