Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006665)
Formula
SVG example
N-demethylation
Reactant Doxepin hydrochloride Product Formaldehyde
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006668 Doxepin hydrochloride (E)-2-hydroxydoxepin Oxidation - Hydrolyzationn Doxepin hydrochloride [1]
MR006666 Doxepin hydrochloride Doxepin N-oxide Oxidation - Oxidationn Doxepin hydrochloride [2]
MR006661 Doxepin hydrochloride N-desmethyldoxepin Oxidation - N-demethylation Doxepin hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004593 Darodipine Formaldehyde Oxidation - N-demethylation; O-demethylation Darodipine [3]
MR003257 Fospropofol Formaldehyde Unclear Fospropofol [4]
MR007845 Fospropofol disodium Formaldehyde Unclear - Unclear Fospropofol disodium [5]
MR004248 Methylamine Formaldehyde Oxidation - Deamination Methylamine [6]
MR000289 N-hydroxymethyl-aripiprazole Formaldehyde Hydrolysis - Hydrolysis Aripiprazole lauroxil [7], [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007846 Formaldehyde Formic acid Unclear - Unclear Fospropofol disodium [5]
References
1 DrugBank(Pharmacology-Metabolism):Doxepin hydrochloride
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 Inhibition of hepatic microsomal drug metabolism in rats by five calcium antagonists
4 DrugBank(Pharmacology-Metabolism)Fospropofol
5 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
6 Methylamine: a new endogenous modulator of neuron firing?
7 Aripiprazole Lauroxil: Pharmacokinetic Profile of This Long-Acting Injectable Antipsychotic in Persons With Schizophrenia J Clin Psychopharmacol. 2017 Jun;37(3):289-295. doi: 10.1097/JCP.0000000000000691.
8 Biological conversion of?aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug Results Pharma Sci. 2014 May 2;4:19-25. doi: 10.1016/j.rinphs.2014.04.002.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.