Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004528)
Formula Reactant WIN 55212-2 Metabolite M1a Product WIN 55212-2 Metabolite M2a
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004519 WIN 55212-2 WIN 55212-2 Metabolite M1a Oxidation - Hydrolyzationn WIN 55212-2 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004526 WIN 55212-2 Metabolite M1a WIN 55212-2 Metabolite M3a Oxidation - Hydrolyzationn WIN 55212-2 [1]
MR004527 WIN 55212-2 Metabolite M1a WIN 55212-2 Metabolite M3b Unclear WIN 55212-2 [1]
MR004520 WIN 55212-2 Metabolite M1a WIN 55212-2 Metabolite M8a Oxidation - Hydrolyzationn WIN 55212-2 [2], [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004530 WIN 55212-2 Metabolite M1c WIN 55212-2 Metabolite M2a Oxidation - Hydrolyzationn WIN 55212-2 [1]
MR004518 WIN 55212-2 Metabolite M4 WIN 55212-2 Metabolite M2a Oxidation - N-dealkylation; O-dealkylation WIN 55212-2 [1]
References
1 Toxicokinetics of new psychoactive substances: plasma protein binding, metabolic stability, and human phase I metabolism of the synthetic cannabinoid WIN 55,212-2 studied using in vitro tools and LC-HR-MS/MS
2 In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist

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