Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004632)
Formula Reactant Ibuprofen Product Ibuprofen Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Ibuprofenyl-CoA ligase (ICL) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004645 Ibuprofen 1-hydroxyibuprofen Oxidation - 1-hydroxylation Ibuprofen [1]
MR004644 Ibuprofen 2-Hydroxyibuprofen Oxidation - 2-hydroxylation Ibuprofen [2]
MR004641 Ibuprofen 3-Hydroxyibuprofen Oxidation - 3-hydroxylation Ibuprofen [2]
MR004643 Ibuprofen Ibuprofen glucuronide Conjugation - O-glucuronidation Ibuprofen [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004633 Ibuprofen Metabolite M1 Ibuprofen Metabolite M2 Unclear Ibuprofen [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218

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