Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004643)
Formula
UGT1A1 ...
SVG example
O-glucuronidation
Reactant Ibuprofen Product Ibuprofen glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004645 Ibuprofen 1-hydroxyibuprofen Oxidation - 1-hydroxylation Ibuprofen [1]
MR004644 Ibuprofen 2-Hydroxyibuprofen Oxidation - 2-hydroxylation Ibuprofen [2]
MR004641 Ibuprofen 3-Hydroxyibuprofen Oxidation - 3-hydroxylation Ibuprofen [2]
MR004632 Ibuprofen Ibuprofen Metabolite M1 Unclear Ibuprofen [3]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218

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